PUBLICATIONS

2024

Lopez, J.A., Romero, L.O., Kaung, W.-L., Maddox, J.W., Vásquez, V., and Lee, A. (2024) Caldendrin is a repressor of PIEZO2 channels and touch sensation in mice. J. Neurosci. 44(10):e1402232023.

Maddox, J.W., Ordemann, G.J., de la Rosa Vázquez, J., Huang, A., Gault, C., Wisner, S.R., Randall, K., Futagi, D., DeVries, S.H., Hoon, M., and A. Lee. (2024) A non-conducting role of the Cav1.4 Ca2+ channel drives homeostatic plasticity at the cone photoreceptor synapse. eLife (in press)

Cheung, H.W., Schouw, A.D., Altunay, Z.M. Maddox, J.W., Kresic, L.C., McAllister, B.C., Caro, K., Alam, S., Huang, A., Pijewski, R.S., Lee, A., Martinelli, D.C. (2024) Creation of a novel allele to express HA epitope-tagged C1QL1 and improved methods for its detection at synapses. FEBS Letters (in press)

2023

Lopez, J.A., Yamamoto, A., Vecchi, J.T., Hagen, J., Lee, K., Sonka, M., Hansen, M., and A. Lee. (2023) Caldendrin represses neurite regeneration and growth in dorsal root ganglion neurons. Sci. Rep. 13:2608

Vecchi J.T., Mullan S., Lopez J.A., Rhomberg M., Yamamoto A., Hallam A., Lee A., Sonka M., Hansen M.R. (2023) Sensitivity of CNN image analysis to multifaceted measurements of neurite growth. BMC Bioinformatics 24: 320

Maziar, A., Critch, TNRHY, Ghosh, S., Rajani, V., Flynn, C.M., Qin, T., Reinhardt, C., Man, KNM, Lee, A., Hell, J.W., Yuan, Q. (2023) Aging differentially affects LTCC function in hippocampal CA1 and piriform cortex pyramidal neurons. Cereb. Cortex 33(4):1489-150.

2022

Koschak, A. and A. Lee. (2022) Cav1 L-type calcium channels in the auditory and visual systems. In: Voltage-gated Calcium Channels, G. Zamponi, N. Weiss, eds., Springer, Cham. https://doi.org/10.1007/978-3-031-08881-0_17

Williams, B., Maddox, J.W., and A. Lee. (2022) Ca2+ channels in retinal function and disease. Ann.Rev.Vis. Sci. doi: 10.1146/annurev-vision-012121-111325

Williams, B., Thomas, J.R., and A. Lee. (2022) Voltage-gated Ca2+ channels and excitation-secretion coupling at the synapse. In: Calcium Signals: From single molecules to physiology. I. Dick, L. Satin, and M. Ben-Johny, ed., IOP Publishing, Bristol

Klomp, A., Omichi R., Iwasa Y., Smith R.J., Usachev Y.M., Russo A.F., Narayanan N.S., and A. Lee. (2022) The voltage-gated Ca2+ channel subunit α2δ-4 regulates locomotor behavior and sensorimotor gating in mice. PLoS One. 17(3):e0263197

Erdogmus, S., Concepcion, A.R., Yamashita, M.,Sidhu, I., Tao, A.Y., Li, W., Rocha, P.P., Huang, B., Garippa, R., Lee, B., Lee, A., Hell, J.W., Lewis, R.S., Prakriya, M., Feske, S. (2022) Cavβ1 regulates T cell expansion and apoptosis independently of voltage-gated Ca2+ channel function. Nat. Commun. 13:2033

2020

Williams, B., Lopez, J., Maddox, J.W., and A. Lee. (2020) Functional impact of a congenital stationary night blindness type 2 mutation depends on subunit composition of Cav1.4 Ca2+ channels. J. Biol. Chem. 295(50):17215-17226

Maddox, J.W., Randall, K.L., Williams, B., Yadav, R.P., Hagen, J, Derr, P.J., Kerov, V., Della Santina, L, Baker S.A., Artemyev, N.O., Hoon, M., and A. Lee. (2020) A dual role for Cav1.4 Ca2+ channels in the molecular and structural organization of the rod photoreceptor synapse. eLife 9:e62184.

Waldner DM, Ito K, Chen LL, Nguyen L, Chow RL, Lee A, Rancourt DE, Tremblay F, Stell WK, Bech-Hansen NT. (2020) Transgenic Expression of Cacna1f Rescues Vision and Retinal Morphology in a Mouse Model of Congenital Stationary Night Blindness 2A (CSNB2A). Transl Vis Sci Technol. 11:19. doi: 10.1167/tvst.9.11.19.

Jin J, Bhatti DL, Lee KW, Medrihan L, Cheng J, Wei J, Zhong P, Yan Z, Kooiker C, Song C, Ahn JH, Obermair GJ, Lee A, Gresack J, Greengard P, Kim Y. (2020) Ahnak scaffolds p11/Anxa2 complex and L-type voltage-gated calcium channel and modulates depressive behavior. Mol Psychiatry. 25(5):1035-1049.

Dolphin AC, Lee A. (2020) Presynaptic calcium channels: specialized control of synaptic neurotransmitter release. Nat Rev Neurosci. 2020 21(4):213-229.

2019

Kim, Y., Bhatti, D., Lee, K.-W., Medihan, L., Cheng, J., Yan, Z., Kooiker, C., Song, C., Ahn, J.-H., Obermair, G., Wei, J., Zhong, P., Lee, A., Gresack, J., and P. Greengard. (2019) Ahnak scaffolds p11/Anxa2 complex and L-type voltage-gated calcium channel and modulates depressive behavior. Mol. Psychiatry, doi: 10.1038/s41380-019-0371-y.

Laird J.G., Gardner S.H., Kopel A.J., Kerov V., Lee A., Baker S.A. (2019) Rescue of rod synapses by induction of Cav a1F in the mature Cav1.4 knockout mouse retina. Invest. Ophthalmol. Vis. Sci. 60:3150-3161.

2018

Thomas, J.R., Hagen, J., Soh, D., and A. Lee. (2018) Molecular moieties masking Ca2+-dependent facilitation of voltage-gated Cav2.2 Ca2+ channels. J. Gen. Physiol. 150: 83-94.

Yang, T., Choi, J.E., Soh, D., Tobin, K., Joiner, M.L., Hansen, M., and A. Lee. (2018) CaBP1 regulates Cav1 L-type Ca2+ channels and their coupling to neurite growth and gene transcription in mouse spiral ganglion neurons. Mol. Cell. Neurosci. 88:342-352.

Yang, T., Hu, N., Pangrsic, T., Green, S.H., Hansen, M. and A. Lee. (2018) Functions of CaBP1 and CaBP2 in the peripheral auditory system. Hearing Res. 364:48-58.

Yang, T., Britt, J.K., Cintrón-Pérez, C.J., Vázquez-Rosa, E., Tobin, K.V., Stalker, G., Hardie, J., Taugher, R.J., Wemmie, J., Pieper, A.A., and A. Lee. (2018) Ca2+ binding protein 1 regulates hippocampal-dependent memory and synaptic plasticity. Neuroscience 380:90-102.

Nanou, E., Lee, A., and W.A. Catterall. (2018) Control of excitation/inhibition balance in a hippocampal circuit by calcium sensor protein regulation of presynaptic calcium channels. J. Neurosci. 38:4430-4440.

Kerov, V., Laird, J.G., Joiner, M.L., Knecht, S., Soh, D., Hagen, J., Gardner, S.H., Gutierrez, W., Yoshimatsu, T., Bhattarai, S., Puthussery, T., Artemyev, N.O., Drack, A.V., Wong, R.O., Baker, S.A., and A. Lee. (2018) α2δ-4 is required for the molecular and structural organization of rod and cone photoreceptor synapses. J. Neurosci. 38: 6145-6160.

Garza-Lopez, E., Lopez, J., Hagen, J., Sheffield, R., Meiner, V. and A. Lee. (2018) Role of a conserved glutamine in the function of voltage-gated Ca2+ channels revealed by a mutation in human CACNA1D. J. Biol. Chem. 293: 14444-14454.

Williams, B.., Haeeleer, F., and A. Lee. (2018) Splicing of an automodulatory domain in Cav1.4 Ca2+ channels confers distinct regulation by calmodulin. J. Gen. Physiol. 150: 1676-1687

2017

Zhu, L., Almaça, J., Dadi, P.K., Hong, H., Sakamoto, W., Rossi, M., Lee, R.J., Vierra, N.C., Lu, H., Cui, Y., McMillin, S.M., Perry, N.A., Gurevich, V.V., Lee, A., Kuo, B., Leapman, R.D., Matschinsky, F.M., Doliba, N.M., Urs, N.M., Caron, M.G., Jacobson, D.A., Caicedo, A., and J. Wess. (2017) β -Arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions. Nat. Commun. 8:14295

Martínez-Rivera, A., Hao, J., Tropea, T.F., Giordano, T.P., Kosovsky, M., Rice, R.C., Lee, A., Huganir, R.L., Striessnig, J., Addy, N.A., Han, S., and A.M. Rajadhyaksha. (2017) Enhancing VTA Cav1.3 L-type Ca2+ channel activity promotes cocaine and mood-related behaviors via overlapping AMPA receptor mechanisms in the nucleus accumbens. Mol. Psychiatry 22:1735-1745

Wang, S., Hagen, J., Hardie, J., Stanika, R.I., Obermair, G.J., Kennedy, M.B., Colbran, R.J., and A. Lee. (2017) Densin-180 controls the trafficking and signaling of voltage-gated Cav1.2 Ca2+ channels at excitatory synapses. J. Neurosci. 37:4679-4691.

Wang, X., Marks, C.R., Perfitt, T.L., Nakagawa, T., Lee, A., Jacobson, D.A., and R.J. Colbran. (2017) A novel mechanism for Ca2+/calmodulin-dependent protein kinase II targeting to L-type Ca2+ channels that initiates long-range signaling to the nucleus. J. Biol. Chem. 292:17324-17336.

2016

Yang, T., Scholl, E.S., Pan, N., Fritzsch, B., Haeseleer, F. and A. Lee. (2016) Expression and localization of CaBP Ca2+ Binding Proteins in the mouse cochlea. PLoS One 25: e0147495.

Haeseleer, F., Williams, B., and A. Lee. (2016) Characterization of C-terminal splice variants of Cav1.4 Ca2+ Channels in human retina. J. Biol. Chem. 291(30):15663-73

Krueger, J.N., Moore, S.J., Parent, R., Lee, A., and G.G. Murphy. (2016) A novel mouse model of the aged brain: Over-expression of the L-type voltage-gated calcium channel Cav1.3. Behav. Brain Res. pii: S0166-4328(16)30418

Thomas, J. and A. Lee. (2016) Measuring Ca2+- Dependent Modulation of Voltage-Gated Ca2+ Channels in HEK-293T Cells. Cold Spring Harb. Protocols 2016(9):pdb.prot087213

Stanika, R., Campiglio, M., Pinggera, A., Lee, A., Striessnig, J., Flucher, B., and G. Obermair. (2016) Splice variants of the Cav1.3 L-type calcium channel regulate dendritic spine morphology. Sci. Reports 6:34528

Sinha, R., Lee, A., Rieke, F., and F. Haeseleer. (2016) Lack of CaBP1/caldendrin or CaBP2 leads to altered ganglion cell responses. eNeuro eNeuro 3(5). pii: ENEURO.0099-16.2016

2015

Lee, A., Wang, S., Williams, B., and F. Haeseleer. (2015) Characterization of Cav1.4 complexes (α11.4, β2, α2δ4) in HEK293T cells and in the retina. J. Biol. Chem. 290, 1505-21.

Joiner, M.A. and A. Lee. (2015) Voltage-gated Cav1 channels in disorders of vision and hearing. Current Mol. Pharmacol. 8(2):143-8.

Scharinger, A., Eckrich, S., Vandael, D. H., Schonig, K., Koschak, A., Hecker, D., Kaur, G., Lee, A., Sah, A., Bartsch, D., Benedetti, B., Lieb, A., Schick, B., Singewald, N., Sinnegger-Brauns, M. J., Carbone, E., Engel, J., and J. Striessnig. (2015) Cell-type-specific tuning of Cav1.3 Ca(2+)-channels by a C-terminal automodulatory domain. Front.Cell.Neurosci. 9:309.

Hardie, J. and A. Lee. (2015) Decalmodulation of Cav1 channels by CaBPs. Channels 8:1-5

Cao, Y., Sarria, I., Fehlhaber, K.E., Kamasawa, N., Orlandi. C., James, K. N., Hazen, J.L., Gardner, M.R., Farzan, M., Lee, A., Baker, S., Baldwin, K., Sampath, A.P., and K.A. Martemyanov. (2015) Mechanism for selective synaptic wiring of rod photoreceptors into the retinal circuitry and its role in vision. Neuron 2015; 87(6):1248-60.

Kerov,V. and A. Lee. (2015) Degrading vision with too much Ca2+. Channels 9:221-222.

2014

Núñez-Santana, F.L., Oh, M., Antion, M. D., Lee. A., Hell. J. W., and J. F. Disterhoft. (2014) Surface L-type Ca2+ channel expression levels are increased in aged hippocampus. Aging Cell 12157: 111-120.

Inagaki, A., Frank C.A., Usachev, Y.M., Benveniste, M., and A. Lee (2014) Pharmacological correction of gating defects in the voltage- gated Cav2.1 Ca2+ channel due to a familial hemiplegic migraine mutation. Neuron 81: 91-102.

Kim, K.Y., Scholl, E. S., Liu, X., Shepherd, A., Haeseleer, F., and A. Lee. (2014) Localization and expression of CaBP1/caldendrin in the mouse brain. Neuroscience 268:33-47.

Lee, A., Fakler, B., Kaczmarek, L.K., and L. L. Isom. (2014) More than a pore: ion channel signaling complexes. J. Neurosci. 34(46): 15159-15169.

2013

Haeseleer, F., Sokal, I., Gregory, F.D., and A. Lee. (2013) Protein phosphatase 2A dephosphorylates CaBP4 in the retina and regulates CaBP4 function. Invest. Ophthalmol. Vis. Sci. 54:1214-1226.

Oz, S., Benmocha, A., Sasson, Y., Sachyani, D., Almagor, L., Lee, A., Hirsch, J. A., and N.Dascal. (2013) Competitive and non-competitive regulation of calcium-dependent inactivation in CaV1.2 L-type Ca2+ channels by calmodulin and Ca2+-binding protein 1. J Biol. Chem. 288:12680-12691.

Hall, D.D., Dai, S., Tseng P.Y., Malik, Z., Nguyen, M., Matt. L., Schnizler, K., Shepherd, A., Mohapatra, D.P., Tsuruta, F., Dolmetsch, R.E., Christel, C. J., Lee, A., Burette, A., Weinberg, R.J., and J. W. Hell. (2013) Competition between a-actinin and Ca2+/calmodulin controls surface retention of the L-type Ca2+ channel Cav1.2. Neuron 78:483-497.

Inagaki, A., and A. Lee. (2013) Developmental alterations in the biophysical properties of Cav1.3 Ca2+ channels in mouse inner hair cells. Channels 7:171-181.

Gregory, F. D., Pangrsic, T., Calin-Jageman, I. E., Moser, T., and A. Lee. (2013) Harmonin enhances voltage-dependent facilitation of Cav1.3 channels and synchronous exocytosis in mouse inner hair cells. J. Physiol. 591:3252-3269.

Knoflach, D., Kerov, V., Sartori, S. B., Obermair, G. J., Schmuckermair, C., Liu, X., Sothilingam, V., Garrido, M. G., Baker, S., Glösmann, M., Schicker, K., Seeliger, M., Lee. A., and A. Koschak.(2013) Cav1.4 IT mouse as model for vision impairment in human Congenital Stationary Night Blindness Type 2. Channels 7:502-512.

Liu, X., Kerov, V., Haeseleer, F., Majumder, A., Artemyev, N., Baker, S. A., and A. Lee. (2013) Dysregulation of Cav1.4 channels disrupts the maturation of photoreceptor synaptic ribbons in congenital stationary night blindness type 2. Channels 7:513-522.

2012

Christel, C. and A. Lee. (2012) Electrophysiological analysis of Ca2+-dependent modulation of voltage-gated Ca2+ channels. Biochem. Biophys. Acta 1820:1243-1252.

Lee, A.S., Ra, S., Rajadhyaksha, A.M., Britt, J.K., Jesus-Cortes, D. H., Gonzales, K. L., Moosmang, S., Lee, A., Hofmann, F., Pieper, A.A., Rajadhyaksha, A.M. (2012) Forebrain elimination of CACNA1C mediates anxiety-like behavior in mice. Mol. Psychiatry. 17:1054-1055.

Lee, A.S., Gonzales, K.L., Lee, A., Moosmang, S., Hofmann, F., Pieper, A.A., Rajadhyaksha, A.M. (2012) Selective genetic deletion of CACNA1C in the mouse prefrontal cortex. Mol. Psychiatry. 17:1051.

Schrauwen, I., Helfmann, S., Inagaki, A., Wolk, F., Tabatabaiefar, M.A., Picher M.M., Sommen, M., ZazoSeco, C., Kremer, H., Dheedene, A., Claes, C., Fransen,E., Reimnitz, F., Diederichsen, U., HashemzadehM., Couke, P., Lee, A., Moser, T., and G. Van Camp. (2012) A mutation in CABP2, expressed in cochlear hair cells, causes autosomal recessive hearing impairment. Am. J. Hum. Genet. 91(4):636-45.

Christel, C.J., Schaer, R., Wang, S., Henzi, T., Kreiner, L., Grabs, D., Schwaller, B., and A. Lee. (2012) Calretinin regulates Ca2+-dependent inactivation and facilitation of Cav2.1 Ca2+ channels through a direct interaction with the α12.1 subunit. J. Biol. Chem. 287:39766-39775.

Christel, C.J., Cardona, N., Mesirca, P., Herrmann, S., Hofmann, F., Striessnig, J., Ludwig, A., Mangoni, M.E.,and A. Lee. (2012) Distinct localization and modulation of Cav1.2 and Cav1.3 L-type Ca2+ channels in mouse sinoatrial node. J. Physiol. 590: 6327-6341.

Zou, J., Lee, A., and J. Yang. (2012) The expression of whirlin and Cav1.3α1 is mutually independent in photoreceptors. Vision Res. 75:53-59

2011

Gregory, F.D., Bryan, K.E., Pangrsic, T., Calin-Jageman, I.E., Moser, T., and A. Lee. (2011) Harmonin inhibits presynaptic Cav1.3 Ca2+ channels in mouse inner hair cells. Nat. Neurosci. 14:1109-1111.

Oz, S., Tsemakhovich, V., Christel, C.J., Lee, A., and N. Dascal. (2011) CaBP1 regulates voltage-dependent inactivation and activation of Cav1.2 (L-type) calcium channels. J. Biol. Chem. 286:13945-13953.

2010

Kreiner, L., Christel, C.J., Benveniste, M., Schwaller, B., and A. Lee. (2010) Compensatory regulation of Cav2.1 Ca2+ channels in cerebellar Purkinje neurons lacking parvalbumin and calbindin D-28k. J. Neurophysiol. 103: 371-381.

Jenkins, M.A., Christel C.J., Jiao, Y., Abiria, S Kim, K., Obermair, G.J., Colbran, R.J., and A. Lee. (2010) Ca2+-dependent facilitation of Cav1.3 Ca2+ channels by densin and Ca2+/calmodulin-dependent protein kinase II. J. Neurosci. 30:5125-5135.

Frank,T., Rutherford, M.A., Strenzke, N., Neef, A., Pangršič , T., Khimich, D., Fetjova, A., Gundelfinger, E.D., Liberman, M.C., Harke, B., Bryan, K.E., Lee, A., Egner, A., Riedel, D., and T. Moser. (2010) Bassoon and the Synaptic Ribbon Organize Ca2+ Channels and Vesicles to Add Release Sites and Promote Refilling. Neuron 68: 724-738.

2009

Haeseleer, F. and A. Lee (2009) CaBP4. UCSD Nature Molecule Pages, doi:10.1038/mp.a004098.01

2008

Yu, K., Xiao, Q., Cui G., Lee, A., and H. C. Hartzell. (2008) The Best Disease-Linked Cl Channel hBest1 Regulates Cav1 (L-type) Ca2+ Channels Via SH3-binding Domains. J. Neurosci. 28 :5660-5670.

Calin-Jageman, I., and A. Lee. (2008) Cav1 L-type Ca2+ channel signaling complexes in neurons J.Neurochem. 105: 573-583.

Tippens, A.L., Pare, J.-F., Moosmang, S., Milner, T.A., Smith, Y., and A. Lee. (2008) Ultrastructural evidence for pre- and post-synaptic localization of Cav1.2 L-type Ca2+ channels in the rat hippocampus. J.Comp.Neurol. 506 :569-583.

Rieke, F., Lee, A., and F. Haeseleer. (2008) Characterization of Ca2+-binding protein 5 knockout mouse retina. Invest. Ophthalmol. Vis. Sci. 49:5126-5135.

2007

Cui, G., Meyer, A.C., Calin-Jageman, I., Neef, J., Haeseleer, F., Moser, T., and A. Lee. (2007) Ca2+-binding proteins tune Ca2+-feedback to Cav1.3 channels in mouse auditory hair cells. J. Physiol. 585: 791-803 (featured in “Perspectives” article by J. Striessnig (2007) J. Physiol. 585: 643-644).

Lee , A., Jimenez, A., Cui, G., and F. Haeseleer. (2007) Phosphorylation of CaBP4 by protein kinase C zeta in photoreceptors. J. Neurosci. 27:12743-12754.

Tippens, A.L., and A. Lee. (2007) Caldendrin: a neuron-specific modulator of Cav1.2 (L-type) Ca2+ channels. J. Biol. Chem. 282:8464-8473.

Calin-Jageman, I., Yu, K., Hall, R.A., Mei, L., and A. Lee. (2007) Erbin enhances voltage-dependent facilitation of Cav1.3 Ca2+ channels through relief of an autoinhibitory domain in the Cav1.3 α1 subunit J. Neurosci. 27:1374-1385.

2006

Kreiner, L. and A. Lee. (2006) Endogenous and exogenous Ca2+ buffers differentially modulate Ca2+-dependent inactivation of Cav2.1 Ca2+ channels. J. Biol. Chem. 281: 4691-4698.

2005

Zhou, H., Yu, K., McCoy, K.L., and A. Lee. (2005) Molecular mechanism for divergent regulation of Cav1.2 Ca2+ channels by calmodulin and Ca2+-binding protein-1. J. Biol. Chem. 280:29612-29619.

Cooper, D.S., Saxena, N.C., Moring, A.G., Lee, A., and I. Choi. (2005) Molecular and functional characterization of the electroneutral Na/HCO3 cotransporter (NBCn1) in rat hippocampal neurons. J. Biol. Chem. 280: 17823-17830.

2004

Haeseleer, F., Imanishi, Y., Maeda, T., Possin, D., Maeda, A., Lee, A., Rieke, F., and K. Palczewski. (2004) Essential role of Ca2+-binding protein 4, a Cav1.4 channel regulator, in photoreceptor synaptic function. Nat. Neurosci. 7: 1079-1087.

Zhou, H., Kim, S.-A., Kirk, E.A., Tippens, A. L., Sun, H., Haeseleer, F., and A. Lee. (2004) Ca2+-binding protein-1 facilitates and forms a postsynaptic complex with Cav1.2 (L-type) Ca2+ channels. J. Neurosci. 24:4698-4708.

2021

Vecchi, J.T., Mullan, S., Lopez, J.A., Hansen, M.R., Sonka, M., and A. Lee (2021) NeuriteNet: A convolutional neural network for assessing morphological parameters of neurite growth. J. Neurosc. Methods 363:109349

Hisatsune, C., Shimada, T., Miyamoto, A., Lee, A., and K.Yamagata. (2021) Tuberous sclerosis complex (TSC) inactivation increases neuronal network activity by enhancing Ca2+ influx via L-type Ca2+ channels J. Neurosci. 41:8134-8149